Immunoglobulin Gene Rearrangement

Source:http://linkedlifedata.com/resource/umls/id/C1512666

NCI: Any process of gene rearrangement that creates a novel junction among the immunoglobuling-coding variable, diversity, joining or constant segments. This process involves sequence recognition, cleavage, excision and ligation by recombinases to create a contiguous protein-coding gene. Immunoglobulin gene rearrangement is involved in generation of antibody diversity.

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