Linked Life Data

MAPK14

Source:http://linkedlifedata.com/resource/umls/id/C1456380

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NCI: Expressed in brain, heart, placenta, pancreas, skeletal muscle, lung, liver, and kidney, by human MAPK14 Gene (MAPK Family), the four isoforms (varying by internal segments and C-termini) of (Ser/Thr) Mitogen-Activated Protein Kinase 14 are involved in oxidative/hypoxic/environmental/genotoxic stress, transcription, cell cycle regulation, and apoptosis. Bound to cytoplasmic PTPRR and activated by cell stress, proinflammatory cytokines, LPS, Thr/Tyr phosphorylation by MAP2K3, MAP2K6, and MAP2K4, and autophosphorylation by MAP3K7IP1/TAB1 interaction, p38 MAPK phosphorylates MAPKAPK2, MAPKAPK5, ELK-1, ATF2, MEF2C, MAX, CDC25B, and p53. p38 is inhibited by DUSP1 and CSAID drugs. (NCI)
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