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| skos:definition |
NCI: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. This protein belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. (LocusLink),NCI: Histone deacetylase 3 is one of three identified histone deacetylases with similarity to the yeast global transcriptional regulator Rpd3p. Two isoforms are produced by alternative splicing and it appears to be expressed ubiquitously. HDAC3 can be found in complexes that include HDAC4 and HDAC5, deacetylases with similarity to yeast Hda1 deacetyl
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| umls:relation |
http://linkedlifedata.com/resource/umls/relation/R107990245,
http://linkedlifedata.com/resource/umls/relation/R107990246,
http://linkedlifedata.com/resource/umls/relation/R128623454,
http://linkedlifedata.com/resource/umls/relation/R109476940,
http://linkedlifedata.com/resource/umls/relation/R54373119,
http://linkedlifedata.com/resource/umls/relation/R54170304,
http://linkedlifedata.com/resource/umls/relation/R54170305,
http://linkedlifedata.com/resource/umls/relation/R54170306,
http://linkedlifedata.com/resource/umls/relation/R109381695,
http://linkedlifedata.com/resource/umls/relation/R109381697,
http://linkedlifedata.com/resource/umls/relation/R54293705,
http://linkedlifedata.com/resource/umls/relation/R54334865,
http://linkedlifedata.com/resource/umls/relation/R54334864,
http://linkedlifedata.com/resource/umls/relation/R69824200,
http://linkedlifedata.com/resource/umls/relation/R69885000
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