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skos:definition |
NCI: Encoded by human oncogene WNT2B Gene (WNT Family), the novel 391-amino acid 43.8 kD (precursor) WNT2B Protein is a homolog of Xenopus Xwnt2 and expressed in fetal brain, lung, and kidney, as well as in a variety of adult tissues. Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine, and colon. Isoform 2 is expressed in fetal brain, lung, and kidney, and in adult brain and testis. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. (NCI)
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