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skos:definition |
CSP: family of peptides originally found as factors that stimulate the phosphorylation of the erbB-2 receptor; multiple variant forms occur due to alternative splicing of their mRNAs; include products from genes NGR1, NGR2 and NGR3.,MSH: A family of peptides originally found as factors that stimulate the phosphorylation of the erbB-2 receptor (RECEPTORS, ERBB-2). Multiple variant forms of NEUREGULINS occur due to alternative splicing of their mRNAs. The NEUREGULINS include products from the three known genes (NGR1; NGR2 and NGR3).,NCI: Neuregulin (heregulin) polypeptides have been shown to interact with and activate the ErbB2, ErbB3 and ErbB4 receptor proteins, and have been found to be essential for the normal development of the cardiovascular, pancreatic and nervous systems. Neuregulins are involved in the normal development of mammary gland, are secreted by breast cancer cells, and can alternatively promote or inhibit breast cancer cell division.
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