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skos:definition |
NCI: An anticancer drug that stops tumor cells from growing by blocking the ability of cells to make DNA. It belongs to the family of drugs called thymidylate synthase inhibitors.,PDQ: A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42625&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42625&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1804" NCI Thesaurus),NCI: A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracell
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