Source:http://linkedlifedata.com/resource/umls/id/C0664494
NCI: Widely expressed by human ADORA3 Gene (GPCR1 Family), 318-aa 36-kDa Adenosine A3 Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains and 3 potential N-glycosylation sites that interacts with a heterotrimeric G protein complex in response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase inhibition. ADORA3 exhibits about 71% homology with A3ar (rat). Released during ischemia, adenosine exerts a potent protective effect through ADORA3 on cardiac ventricular cells. ADORA3 may have a role in reproduction.,MSH: A subtype of ADENOSINE RECEPTOR that is found expressed in a variety of locations including the BRAIN and endocrine tissues. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.