Source:http://linkedlifedata.com/resource/umls/id/C0594374
MSH: Compounds that inhibit the activity of DNA TOPOISOMERASE I.,NCI: Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis.