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skos:definition |
NCI: Encoded by human HMOX1 Gene (Heme Oxygenase Family), 288 aa 33-kD conserved Heme Oxygenase 1 is a microsomal enzyme (highest activity in spleen) involved in heme catabolism and highly inducible by its heme substrate, heavy metals, bromobenzene, endotoxin, oxidizing agents, and UV-A. A protective antioxidant, heme oxygenase cleaves the alpha methene bridge of the heme ring to form biliverdin (converted to bilirubin by biliverdin reductase) and carbon monoxide, a putative neurotransmitter. (NCI),MSH: A ubiquitous stress-responsive enzyme that catalyzes the oxidative cleavage of HEME to yield IRON; CARBON MONOXIDE; and BILIVERDIN.
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