|
skos:definition |
NCI: The pi class glutathione S-transferase is believed to play an important role in detoxification. It is encoded by the GSTP1 gene.,NCI: GST-pi is the anionic isozyme of glutathione S-transferase. GST enzymes play an important role in detoxification by conjugating hydrophobic and electrophilic compounds with reduced glutathione. GST-pi appears to be present in all tissues, with the exception of red blood cells, and is over expressed in multidrug-resistant cells. GST-pi may be fatty acid ethyl ester synthase III, a heart enzyme that nonoxidatively metabolizes ethanol. (from OMIM 134660 and NCI),MSH: A glutathione transferase that catalyzes the conjugation of electrophilic substrates to GLUTATHIONE. This enzyme has been shown to provide cellular protection against redox-mediated damage by FREE RADICALS.
|
