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skos:definition |
CSP: genetic predisposition toward the development of immediate (type I) hypersensitivity reactions against common environmental antigens (atopic allergy); the most common clinical manifestation is allergic rhinitis; bronchial asthmas, atopic dermatitis and food allergy also occur.,CHV: an allergic reaction with strong family tendencies,NCI: A genetic predisposition to form IgE antibodies in response to exposure to allergens and therefore, for the development of immediate (type I) hypersensitivity and atopic conditions, such as allergic rhinitis; bronchial asthma, atopic dermatitis, and food allergy. Mutations of specific alleles on the long arm of chromosome 5 have been associated with higher levels of IL-4 and IgE and are known as IL-4 promoter polymorphisms.
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