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skos:definition |
MSH: A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.,GO: Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage. [GOC:ns],NCI: A structural chromosomal abnormality caused by the spontaneous or induced breakage of a chromosome. It may result in DNA sequence deletions, chromosomal translocations, or chromosomal inversions.
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