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skos:definition |
NCI: Expressed in brain, placenta, lung, liver, kidney, and pancreas by human EEF1A1 Gene (EF-Tu/EF-1A Family), 462-aa 50-kDa cytoplasmic Elongation Factor 1A1 is the alpha subunit of elongation factor-1 (EEF1) complex and contains domains that bind guanine nucleotides, 80S ribosomes, and aminoacyl-tRNAs. Involved in enzymatic delivery and GTP-dependent binding of aminoacyl-tRNAs to the A-site of 80S ribosomes during protein biosynthesis, EEF1A1 interacts with the beta subunit of EEF1 to hydrolyze GTP to GDP. (NCI)
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