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skos:definition |
CSP: 1(3-hydroxy-2-phosphonomethoxypropyl) cytosine; potent selective inhibitor of human cytomegalovirus replication; used in CMV retinitis therapy.,NCI: A drug used to treat infection caused by viruses.,PDQ: A synthetic, acyclic, monophosphate nucleotide analog of deoxycytidine with antiviral activity, and mostly used against cytomegalovirus (CMV). After incorporation into the host cell, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42545&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42545&idtype=1&closed=1" closed clinical trials using this agent. ("http://
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