pemetrexed

Source:http://linkedlifedata.com/resource/umls/id/C0210657

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Predicate	Object
rdf:type	umls-semnetwork:T109, umls-semnetwork:T121, skos:Concept
calbc:hasCorrelation	calbc-group:CHEM, calbc-group:CONC, calbc-group:PHYS, calbc-group:PROC
skos:definition	NCI: A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis.
skos:inScheme	lld:umls
skos:broader	umls-concept:C0003377, umls-concept:C0003392, umls-concept:C0014432, umls-concept:C0016411
skos:narrower	umls-concept:C0251353, umls-concept:C0936142, umls-concept:C1101816
skos-xl:prefLabel	umls-label:A2303548
skos-xl:altLabel	umls-label:A0427294, umls-label:A0437150, umls-label:A10408618, umls-label:A10811442, umls-label:A10811443, umls-label:A11915185, umls-label:A11916016, umls-label:A11916752, umls-label:A11919168, umls-label:A12790859, umls-label:A12807838, umls-label:A12812038, umls-label:A12817150, umls-label:A15560118, umls-label:A17906651, umls-label:A17906652, umls-label:A17954762, umls-label:A17979049, umls-label:A17979050, umls-label:A18002702, umls-label:A18026443, umls-label:A18560260, umls-label:A18690106, umls-label:A1894697, umls-label:A19373949, umls-label:A19703567, umls-label:A4368106, umls-label:A8452064, umls-label:A8482624
umls:relation	http://linkedlifedata.com/resource/umls/relation/R112189338, http://linkedlifedata.com/resource/umls/relation/R112189356, http://linkedlifedata.com/resource/umls/relation/R112182208, http://linkedlifedata.com/resource/umls/relation/R112182209, http://linkedlifedata.com/resource/umls/relation/R116397702, http://linkedlifedata.com/resource/umls/relation/R116397703, http://linkedlifedata.com/resource/umls/relation/R116397704, http://linkedlifedata.com/resource/umls/relation/R116397705, http://linkedlifedata.com/resource/umls/relation/R116397706, http://linkedlifedata.com/resource/umls/relation/R116397707, http://linkedlifedata.com/resource/umls/relation/R116397708, http://linkedlifedata.com/resource/umls/relation/R112182210, http://linkedlifedata.com/resource/umls/relation/R126084206, http://linkedlifedata.com/resource/umls/relation/R129883893, http://linkedlifedata.com/resource/umls/relation/R112182211, http://linkedlifedata.com/resource/umls/relation/R55143540, http://linkedlifedata.com/resource/umls/relation/R55143545, http://linkedlifedata.com/resource/umls/relation/R45060443, http://linkedlifedata.com/resource/umls/relation/R49117982, http://linkedlifedata.com/resource/umls/relation/R45438176, http://linkedlifedata.com/resource/umls/relation/R45438177, http://linkedlifedata.com/resource/umls/relation/R129808183, http://linkedlifedata.com/resource/umls/relation/R60458196, http://linkedlifedata.com/resource/umls/relation/R69666405, http://linkedlifedata.com/resource/umls/relation/R99707084, http://linkedlifedata.com/resource/umls/relation/R69873611, http://linkedlifedata.com/resource/umls/relation/R69755126, http://linkedlifedata.com/resource/umls/relation/R116417586, http://linkedlifedata.com/resource/umls/relation/R116417587, http://linkedlifedata.com/resource/umls/relation/R116432104, http://linkedlifedata.com/resource/umls/relation/R116439350, http://linkedlifedata.com/resource/umls/relation/R116086482, http://linkedlifedata.com/resource/umls/relation/R116060465, http://linkedlifedata.com/resource/umls/relation/R116060466, http://linkedlifedata.com/resource/umls/relation/R116235914, http://linkedlifedata.com/resource/umls/relation/R116206285, http://linkedlifedata.com/resource/umls/relation/R116206286, http://linkedlifedata.com/resource/umls/relation/R116439351, http://linkedlifedata.com/resource/umls/relation/R119373517, http://linkedlifedata.com/resource/umls/relation/R119373516, http://linkedlifedata.com/resource/umls/relation/R119397668, http://linkedlifedata.com/resource/umls/relation/R116446433, http://linkedlifedata.com/resource/umls/relation/R115986381, http://linkedlifedata.com/resource/umls/relation/R115986380, http://linkedlifedata.com/resource/umls/relation/R115986382, http://linkedlifedata.com/resource/umls/relation/R116453545, http://linkedlifedata.com/resource/umls/relation/R119387315, http://linkedlifedata.com/resource/umls/relation/R112201356, http://linkedlifedata.com/resource/umls/relation/R126077616, http://linkedlifedata.com/resource/umls/relation/R129363396, http://linkedlifedata.com/resource/umls/relation/R129363397, http://linkedlifedata.com/resource/umls/relation/R129898200, http://linkedlifedata.com/resource/umls/relation/R112201900, http://linkedlifedata.com/resource/umls/relation/R32154010