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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.,CSP: nucleoside analog; used as an antiviral agent.,NCI: A drug that belongs to the family of drugs called nucleoside analogues. It is used to treat infection caused by viruses.,PDQ: A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41064&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41064&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:8
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0676775,
umls-concept:C0701312,
umls-concept:C0701313,
umls-concept:C0949534,
umls-concept:C0961772,
umls-concept:C1175140,
umls-concept:C1259544,
umls-concept:C1452280,
umls-concept:C1565496,
umls-concept:C1682321,
umls-concept:C1958428,
umls-concept:C2351228,
umls-concept:C2742607
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skos-xl:prefLabel |
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skos-xl:altLabel |
umls-label:A0177074,
umls-label:A0363986,
umls-label:A0363987,
umls-label:A0363988,
umls-label:A0587494,
umls-label:A0835930,
umls-label:A0835931,
umls-label:A0835932,
umls-label:A10338051,
umls-label:A10763907,
umls-label:A10768596,
umls-label:A10783025,
umls-label:A10783026,
umls-label:A10783736,
umls-label:A11577587,
umls-label:A11867487,
umls-label:A11915081,
umls-label:A11917416,
umls-label:A11918251,
umls-label:A12787568,
umls-label:A12812494,
umls-label:A1302311,
umls-label:A1302314,
umls-label:A1305331,
umls-label:A16387598,
umls-label:A16488278,
umls-label:A17040376,
umls-label:A17906464,
umls-label:A17930779,
umls-label:A17954576,
umls-label:A17954577,
umls-label:A17978853,
umls-label:A17978854,
umls-label:A17978855,
umls-label:A18002510,
umls-label:A18245893,
umls-label:A18652134,
umls-label:A18652135,
umls-label:A4345350,
umls-label:A4352022,
umls-label:A4355556,
umls-label:A4356736,
umls-label:A7575554,
umls-label:A7583935,
umls-label:A7643793,
umls-label:A8449959,
umls-label:A8482064
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R112187991,
http://linkedlifedata.com/resource/umls/relation/R64579662,
http://linkedlifedata.com/resource/umls/relation/R112189044,
http://linkedlifedata.com/resource/umls/relation/R32110520,
http://linkedlifedata.com/resource/umls/relation/R32110519,
http://linkedlifedata.com/resource/umls/relation/R32110518,
http://linkedlifedata.com/resource/umls/relation/R120554937,
http://linkedlifedata.com/resource/umls/relation/R120554938,
http://linkedlifedata.com/resource/umls/relation/R120554939,
http://linkedlifedata.com/resource/umls/relation/R120554941,
http://linkedlifedata.com/resource/umls/relation/R120554942,
http://linkedlifedata.com/resource/umls/relation/R120554943,
http://linkedlifedata.com/resource/umls/relation/R120554944,
http://linkedlifedata.com/resource/umls/relation/R120554945,
http://linkedlifedata.com/resource/umls/relation/R120554946,
http://linkedlifedata.com/resource/umls/relation/R120554947,
http://linkedlifedata.com/resource/umls/relation/R120554948,
http://linkedlifedata.com/resource/umls/relation/R120554950,
http://linkedlifedata.com/resource/umls/relation/R120554951,
http://linkedlifedata.com/resource/umls/relation/R120554952,
http://linkedlifedata.com/resource/umls/relation/R120554954,
http://linkedlifedata.com/resource/umls/relation/R120554955
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