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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.,NCI: A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.,PDQ: A macrolide isolated from the fungus Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42009&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.a
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0123418,
umls-concept:C0171689,
umls-concept:C0247035,
umls-concept:C0248874,
umls-concept:C0254553,
umls-concept:C0254554,
umls-concept:C0385848,
umls-concept:C0386746,
umls-concept:C0387605,
umls-concept:C0387931,
umls-concept:C0389279,
umls-concept:C0389280,
umls-concept:C0389281,
umls-concept:C0389282,
umls-concept:C0389283,
umls-concept:C0532779,
umls-concept:C0541113,
umls-concept:C0541116,
umls-concept:C0651827,
umls-concept:C0662219,
umls-concept:C0662221,
umls-concept:C0662224,
umls-concept:C0670356,
umls-concept:C0675261,
umls-concept:C0678125,
umls-concept:C0729218,
umls-concept:C0729219,
umls-concept:C0762201,
umls-concept:C0768669,
umls-concept:C0771204,
umls-concept:C0909535,
umls-concept:C0909969,
umls-concept:C0910891,
umls-concept:C0939455,
umls-concept:C1099414,
umls-concept:C1122631,
umls-concept:C1142708,
umls-concept:C1451737,
umls-concept:C1451920,
umls-concept:C1528199,
umls-concept:C1576966,
umls-concept:C1619944,
umls-concept:C1623355,
umls-concept:C2002762,
umls-concept:C3249359
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skos-xl:prefLabel |
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skos-xl:altLabel |
umls-label:A0527074,
umls-label:A0586765,
umls-label:A0836158,
umls-label:A0836159,
umls-label:A0836160,
umls-label:A10338533,
umls-label:A10765482,
umls-label:A10768597,
umls-label:A10769586,
umls-label:A10806883,
umls-label:A10806884,
umls-label:A11826459,
umls-label:A11919961,
umls-label:A15533337,
umls-label:A16765394,
umls-label:A17132372,
umls-label:A17905981,
umls-label:A17905982,
umls-label:A18002023,
umls-label:A18002024,
umls-label:A18025773,
umls-label:A18025774,
umls-label:A18362007,
umls-label:A18688153,
umls-label:A4355602,
umls-label:A7578351,
umls-label:A8436725,
umls-label:A8482187
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R112189639,
http://linkedlifedata.com/resource/umls/relation/R112190739,
http://linkedlifedata.com/resource/umls/relation/R32109476,
http://linkedlifedata.com/resource/umls/relation/R32109478,
http://linkedlifedata.com/resource/umls/relation/R32109479,
http://linkedlifedata.com/resource/umls/relation/R32109477,
http://linkedlifedata.com/resource/umls/relation/R120527025,
http://linkedlifedata.com/resource/umls/relation/R120527026,
http://linkedlifedata.com/resource/umls/relation/R120527027,
http://linkedlifedata.com/resource/umls/relation/R120527029,
http://linkedlifedata.com/resource/umls/relation/R120527030,
http://linkedlifedata.com/resource/umls/relation/R120527031
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