transcription factor USF

Source:http://linkedlifedata.com/resource/umls/id/C0076925

NCI: The upstream stimulatory factor is a ubiquitously expressed cellular transcription factor that binds to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters. Purified USF consists of 2 related polypeptides of 43 and 44 kD encoded by USF1 and USF2, respectively. USF is known to be involved in the regulation of many gene with direct and indirect roles in cancer. (from OMIM and NCI),NCI: The ubiquitous bZIP transcription factor Upstream Stimulatory Factor binds to many viral and cellular promoters. USF consists of two related polypeptides USF1 and USF2. USF function may support the host immune response by promoting MHC class I and class II antigen expression. (from OMIM 191523, 600390 and NCI),MSH: Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a variety of GENES involved in carbohydrate and lipid metabolism.

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