Source:http://linkedlifedata.com/resource/umls/id/C0064494
NCI: An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.,PDQ: An orally-active agent with potential antineoplastic activity. Carboxyamidotriazole binds to and inhibits non-voltage-operated Ca2+ channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores and resulting in the disruption of calcium channel-mediated signal transduction and inhibition of vascular endothelial growth factor (VEGF) signaling, endothelial proliferation, and angiogenesis. This agent may also inhibit tumor cell growth, invasion and metastasis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41613&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41613&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1141" NCI Thesaurus),NCI: An orally-active agent with potential antineoplastic activity. Carboxyamidotriazole bi