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rdf:type |
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calbc:hasCorrelation |
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skos:definition |
NCI: The synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties. Hydrocortisone acetate initially binds to the cytoplasmic glucocorticoid receptor; then the receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes.
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0072058,
umls-concept:C0116328,
umls-concept:C0305743,
umls-concept:C0305744,
umls-concept:C0307391,
umls-concept:C0591101,
umls-concept:C0591620,
umls-concept:C0699388,
umls-concept:C0699399,
umls-concept:C0699646,
umls-concept:C0718593,
umls-concept:C0719170,
umls-concept:C0719533,
umls-concept:C0720232,
umls-concept:C0720917,
umls-concept:C0720957,
umls-concept:C0721552,
umls-concept:C0953176,
umls-concept:C0953177,
umls-concept:C0953178,
umls-concept:C0953179,
umls-concept:C0953180,
umls-concept:C1170559,
umls-concept:C1589020,
umls-concept:C1589083,
umls-concept:C1602089,
umls-concept:C1612387,
umls-concept:C1701434,
umls-concept:C1829330,
umls-concept:C1962029,
umls-concept:C1996146,
umls-concept:C2241626,
umls-concept:C2365578,
umls-concept:C2702197,
umls-concept:C2938171,
umls-concept:C2938173,
umls-concept:C2938434,
umls-concept:C2938437,
umls-concept:C2938472,
umls-concept:C2938480,
umls-concept:C2938500,
umls-concept:C2946461,
umls-concept:C2949072,
umls-concept:C2981060,
umls-concept:C3163100,
umls-concept:C3163378,
umls-concept:C3163507,
umls-concept:C3249167,
umls-concept:C3249181,
umls-concept:C3254919,
umls-concept:C3464038,
umls-concept:C3464181
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skos-xl:prefLabel |
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skos-xl:altLabel |
umls-label:A0146007,
umls-label:A0174678,
umls-label:A0194230,
umls-label:A0194237,
umls-label:A11569767,
umls-label:A11569768,
umls-label:A12794300,
umls-label:A12794301,
umls-label:A14209836,
umls-label:A1528330,
umls-label:A16791856,
umls-label:A17905186,
umls-label:A17905187,
umls-label:A17953288,
umls-label:A17953289,
umls-label:A17977601,
umls-label:A18024970,
umls-label:A18024971,
umls-label:A18632205,
umls-label:A8436870,
umls-label:A8482365
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R112187522,
http://linkedlifedata.com/resource/umls/relation/R112187961,
http://linkedlifedata.com/resource/umls/relation/R112188284,
http://linkedlifedata.com/resource/umls/relation/R01365026,
http://linkedlifedata.com/resource/umls/relation/R01365027,
http://linkedlifedata.com/resource/umls/relation/R54604424,
http://linkedlifedata.com/resource/umls/relation/R57822779,
http://linkedlifedata.com/resource/umls/relation/R01364999,
http://linkedlifedata.com/resource/umls/relation/R01365005,
http://linkedlifedata.com/resource/umls/relation/R01365009,
http://linkedlifedata.com/resource/umls/relation/R01365011,
http://linkedlifedata.com/resource/umls/relation/R01365017,
http://linkedlifedata.com/resource/umls/relation/R01365018,
http://linkedlifedata.com/resource/umls/relation/R01365019
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