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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
CSP: family of transcription factors that stimulate transcription of target genes in response to hormonal signals that elevate intracellular cAMP levels.,NCI: Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB Family) are conserved nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI),MSH: A protein that has been sho
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0384817,
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umls-concept:C1701545,
umls-concept:C2606198,
umls-concept:C2974990
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skos-xl:prefLabel |
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skos-xl:altLabel |
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R28523373,
http://linkedlifedata.com/resource/umls/relation/R28525071,
http://linkedlifedata.com/resource/umls/relation/R05678125,
http://linkedlifedata.com/resource/umls/relation/R00899102,
http://linkedlifedata.com/resource/umls/relation/R44025762,
http://linkedlifedata.com/resource/umls/relation/R44025760,
http://linkedlifedata.com/resource/umls/relation/R43990870,
http://linkedlifedata.com/resource/umls/relation/R44025761,
http://linkedlifedata.com/resource/umls/relation/R05762665,
http://linkedlifedata.com/resource/umls/relation/R05762664,
http://linkedlifedata.com/resource/umls/relation/R05762666,
http://linkedlifedata.com/resource/umls/relation/R05762667,
http://linkedlifedata.com/resource/umls/relation/R44027383,
http://linkedlifedata.com/resource/umls/relation/R119414694,
http://linkedlifedata.com/resource/umls/relation/R28474472,
http://linkedlifedata.com/resource/umls/relation/R28474743,
http://linkedlifedata.com/resource/umls/relation/R44811805,
http://linkedlifedata.com/resource/umls/relation/R54294854,
http://linkedlifedata.com/resource/umls/relation/R54374036,
http://linkedlifedata.com/resource/umls/relation/R54435764,
http://linkedlifedata.com/resource/umls/relation/R54172850,
http://linkedlifedata.com/resource/umls/relation/R109383683,
http://linkedlifedata.com/resource/umls/relation/R54172851,
http://linkedlifedata.com/resource/umls/relation/R109176900,
http://linkedlifedata.com/resource/umls/relation/R54374037,
http://linkedlifedata.com/resource/umls/relation/R109478206,
http://linkedlifedata.com/resource/umls/relation/R54294855,
http://linkedlifedata.com/resource/umls/relation/R124637891,
http://linkedlifedata.com/resource/umls/relation/R124701774,
http://linkedlifedata.com/resource/umls/relation/R124701775,
http://linkedlifedata.com/resource/umls/relation/R69835275,
http://linkedlifedata.com/resource/umls/relation/R69864829,
http://linkedlifedata.com/resource/umls/relation/R69787011,
http://linkedlifedata.com/resource/umls/relation/R69784725,
http://linkedlifedata.com/resource/umls/relation/R124701776,
http://linkedlifedata.com/resource/umls/relation/R124701777,
http://linkedlifedata.com/resource/umls/relation/R124701778,
http://linkedlifedata.com/resource/umls/relation/R124701779,
http://linkedlifedata.com/resource/umls/relation/R69771704,
http://linkedlifedata.com/resource/umls/relation/R120541929,
http://linkedlifedata.com/resource/umls/relation/R120541930,
http://linkedlifedata.com/resource/umls/relation/R120541932,
http://linkedlifedata.com/resource/umls/relation/R120541933,
http://linkedlifedata.com/resource/umls/relation/R120541934
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