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rdf:type |
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calbc:hasCorrelation |
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skos:definition |
CHV: a drug used to treat heartburn,NCI: A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0286036,
umls-concept:C0592289,
umls-concept:C0740025,
umls-concept:C1174766,
umls-concept:C1310657,
umls-concept:C1310658,
umls-concept:C1310659,
umls-concept:C1310660,
umls-concept:C1310661,
umls-concept:C1310662,
umls-concept:C1310663,
umls-concept:C1310664,
umls-concept:C2609580
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skos-xl:prefLabel |
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skos-xl:altLabel |
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umls-label:A1144739,
umls-label:A11767963,
umls-label:A17111856,
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umls-label:A20019087,
umls-label:A20022335,
umls-label:A7581202,
umls-label:A8437812,
umls-label:A8482241
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R112187473,
http://linkedlifedata.com/resource/umls/relation/R01357733,
http://linkedlifedata.com/resource/umls/relation/R49864389,
http://linkedlifedata.com/resource/umls/relation/R25106945,
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http://linkedlifedata.com/resource/umls/relation/R49864388,
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http://linkedlifedata.com/resource/umls/relation/R55155254,
http://linkedlifedata.com/resource/umls/relation/R01365271,
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http://linkedlifedata.com/resource/umls/relation/R25106950,
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http://linkedlifedata.com/resource/umls/relation/R112842668,
http://linkedlifedata.com/resource/umls/relation/R49864391,
http://linkedlifedata.com/resource/umls/relation/R112406265,
http://linkedlifedata.com/resource/umls/relation/R49864393,
http://linkedlifedata.com/resource/umls/relation/R114282996,
http://linkedlifedata.com/resource/umls/relation/R114282997,
http://linkedlifedata.com/resource/umls/relation/R132425178,
http://linkedlifedata.com/resource/umls/relation/R132425179,
http://linkedlifedata.com/resource/umls/relation/R55155255,
http://linkedlifedata.com/resource/umls/relation/R112188365,
http://linkedlifedata.com/resource/umls/relation/R32144082,
http://linkedlifedata.com/resource/umls/relation/R32144092,
http://linkedlifedata.com/resource/umls/relation/R32144081,
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