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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.,CSP: D isomer of quinine; sometimes used as an antimalarial in patients who cannot tolerate quinine.,PDQ: An alkaloid extracted from the bark of the Cinchona tree with class 1A antiarrhythmic and antimalarial effects. Quinidine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the sodium influx required for the initiation and conduction of impulses resulting in an increase of the threshold for excitation and decreased depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD r
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0034415,
umls-concept:C0034436,
umls-concept:C0047465,
umls-concept:C0047469,
umls-concept:C0047494,
umls-concept:C0063103,
umls-concept:C0072869,
umls-concept:C0072870,
umls-concept:C0084273,
umls-concept:C0136568,
umls-concept:C0139696,
umls-concept:C0139697,
umls-concept:C0246317,
umls-concept:C0604634,
umls-concept:C0612147,
umls-concept:C0630382,
umls-concept:C0641351,
umls-concept:C0719165,
umls-concept:C0722960,
umls-concept:C0722961,
umls-concept:C1097294,
umls-concept:C1122274,
umls-concept:C1262584,
umls-concept:C1262586,
umls-concept:C1564018,
umls-concept:C1564019,
umls-concept:C1564020,
umls-concept:C1564021,
umls-concept:C1601325,
umls-concept:C1601328,
umls-concept:C1698934,
umls-concept:C2607460,
umls-concept:C2936691,
umls-concept:C2936711,
umls-concept:C2954623,
umls-concept:C3491511
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skos-xl:prefLabel |
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skos-xl:altLabel |
umls-label:A0037852,
umls-label:A0108636,
umls-label:A0108637,
umls-label:A0487974,
umls-label:A0487975,
umls-label:A0542381,
umls-label:A10336325,
umls-label:A10768177,
umls-label:A11793157,
umls-label:A12799533,
umls-label:A17879689,
umls-label:A17928062,
umls-label:A17951879,
umls-label:A17976164,
umls-label:A18047821,
umls-label:A18047822,
umls-label:A18400420,
umls-label:A18686442,
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umls-label:A8481925
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R112184702,
http://linkedlifedata.com/resource/umls/relation/R112186731,
http://linkedlifedata.com/resource/umls/relation/R32106380,
http://linkedlifedata.com/resource/umls/relation/R32106381,
http://linkedlifedata.com/resource/umls/relation/R44808296,
http://linkedlifedata.com/resource/umls/relation/R44808297,
http://linkedlifedata.com/resource/umls/relation/R44808298,
http://linkedlifedata.com/resource/umls/relation/R44808299,
http://linkedlifedata.com/resource/umls/relation/R120432746,
http://linkedlifedata.com/resource/umls/relation/R120432747,
http://linkedlifedata.com/resource/umls/relation/R120432748,
http://linkedlifedata.com/resource/umls/relation/R120432750,
http://linkedlifedata.com/resource/umls/relation/R120432751,
http://linkedlifedata.com/resource/umls/relation/R120432752
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