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skos:definition |
PDQ: Pentavalent antimony (Sb) in differential complex formation with gluconic acid with established leishmanicidal use and potential antitumor activity. The Sb moiety of sodium stibogluconate (SSG) may inhibit protein tyrosine phophorylases (PTPases) by covalently modifying sulfhydryl groups in PTPase cysteine residues, resulting in specific inactivation of SH2 domain-containing tyrosine phosphatases-1 and -2 (SHP-1 and SHP-2), PTPases which negatively regulate interferon (IFN) signaling; enhancement of IFN-induced Stat1 tyrosine phosphorylation; and induction of cellular protein tyrosine phosphorylation. SSG in combination with IFN-alpha may synergize to overcome tumor cell resistance to IFN-alpha-mediated apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=475763&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=475763&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp
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skos-xl:prefLabel |
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umls-label:A0117634,
umls-label:A0119669,
umls-label:A0119670,
umls-label:A10336444,
umls-label:A11915442,
umls-label:A11920273,
umls-label:A12791270,
umls-label:A12816662,
umls-label:A12816663,
umls-label:A18574621,
umls-label:A18630443,
umls-label:A19026134,
umls-label:A19039054,
umls-label:A7763253
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R28440338,
http://linkedlifedata.com/resource/umls/relation/R112186871,
http://linkedlifedata.com/resource/umls/relation/R28518371,
http://linkedlifedata.com/resource/umls/relation/R112186900,
http://linkedlifedata.com/resource/umls/relation/R112186901,
http://linkedlifedata.com/resource/umls/relation/R41130733,
http://linkedlifedata.com/resource/umls/relation/R112169642,
http://linkedlifedata.com/resource/umls/relation/R112169643,
http://linkedlifedata.com/resource/umls/relation/R112169644,
http://linkedlifedata.com/resource/umls/relation/R112169645,
http://linkedlifedata.com/resource/umls/relation/R108024933,
http://linkedlifedata.com/resource/umls/relation/R45441549,
http://linkedlifedata.com/resource/umls/relation/R45441550,
http://linkedlifedata.com/resource/umls/relation/R129811765,
http://linkedlifedata.com/resource/umls/relation/R60461554,
http://linkedlifedata.com/resource/umls/relation/R60453246,
http://linkedlifedata.com/resource/umls/relation/R60454303,
http://linkedlifedata.com/resource/umls/relation/R124694450,
http://linkedlifedata.com/resource/umls/relation/R69667713,
http://linkedlifedata.com/resource/umls/relation/R69694497,
http://linkedlifedata.com/resource/umls/relation/R69708004,
http://linkedlifedata.com/resource/umls/relation/R69734838,
http://linkedlifedata.com/resource/umls/relation/R99710365,
http://linkedlifedata.com/resource/umls/relation/R69805113,
http://linkedlifedata.com/resource/umls/relation/R69867858,
http://linkedlifedata.com/resource/umls/relation/R41150226,
http://linkedlifedata.com/resource/umls/relation/R112203859,
http://linkedlifedata.com/resource/umls/relation/R31974082,
http://linkedlifedata.com/resource/umls/relation/R02957172,
http://linkedlifedata.com/resource/umls/relation/R02957173,
http://linkedlifedata.com/resource/umls/relation/R69887238,
http://linkedlifedata.com/resource/umls/relation/R124729863
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