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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: A highly effective inhibitor of gastric acid secretion used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits the H(+)-K(+)-ATPase (H(+)-K(+)-EXCHANGING ATPASE) in the proton pump of GASTRIC PARIETAL CELLS.,CSP: substituted benzimidazole used as a gastric acid secretion inhibitor.,NCI: A drug that inhibits gastric acid secretion.,PDQ: A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic properties and does not antagonize histamine H2 receptors. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42309&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLin
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0069481,
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umls-concept:C2918124
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skos-xl:prefLabel |
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R49863021,
http://linkedlifedata.com/resource/umls/relation/R49863020,
http://linkedlifedata.com/resource/umls/relation/R104210782,
http://linkedlifedata.com/resource/umls/relation/R133618055,
http://linkedlifedata.com/resource/umls/relation/R114282977,
http://linkedlifedata.com/resource/umls/relation/R55154596,
http://linkedlifedata.com/resource/umls/relation/R112186351,
http://linkedlifedata.com/resource/umls/relation/R32105006,
http://linkedlifedata.com/resource/umls/relation/R32105007,
http://linkedlifedata.com/resource/umls/relation/R32105008,
http://linkedlifedata.com/resource/umls/relation/R32105009,
http://linkedlifedata.com/resource/umls/relation/R120389971,
http://linkedlifedata.com/resource/umls/relation/R120389972,
http://linkedlifedata.com/resource/umls/relation/R120389973,
http://linkedlifedata.com/resource/umls/relation/R120389975,
http://linkedlifedata.com/resource/umls/relation/R120389976,
http://linkedlifedata.com/resource/umls/relation/R120389977,
http://linkedlifedata.com/resource/umls/relation/R120389978,
http://linkedlifedata.com/resource/umls/relation/R120389979,
http://linkedlifedata.com/resource/umls/relation/R120389980,
http://linkedlifedata.com/resource/umls/relation/R120389981,
http://linkedlifedata.com/resource/umls/relation/R120389982,
http://linkedlifedata.com/resource/umls/relation/R120389984,
http://linkedlifedata.com/resource/umls/relation/R120389985,
http://linkedlifedata.com/resource/umls/relation/R120389986,
http://linkedlifedata.com/resource/umls/relation/R120389988,
http://linkedlifedata.com/resource/umls/relation/R120389989,
http://linkedlifedata.com/resource/umls/relation/R120389990,
http://linkedlifedata.com/resource/umls/relation/R120389991
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