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skos:definition |
CSP: replacement of the bone marrow by fibrous tissue, occurring in association with a myeloproliferative disorder or secondary to another unrelated condition.,NCI: A disorder in which the bone marrow is replaced by fibrous tissue.,NCI: A partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma). --2003
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