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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.,NCI: An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease).,PDQ: A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39506&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39506&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C664"
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0164650,
umls-concept:C0164921,
umls-concept:C0623365,
umls-concept:C0632864,
umls-concept:C0702004,
umls-concept:C0702006,
umls-concept:C0702007,
umls-concept:C1513353,
umls-concept:C1522708,
umls-concept:C1522709,
umls-concept:C2742379
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skos-xl:prefLabel |
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skos-xl:altLabel |
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R112186150,
http://linkedlifedata.com/resource/umls/relation/R32104175,
http://linkedlifedata.com/resource/umls/relation/R32104176,
http://linkedlifedata.com/resource/umls/relation/R32104174,
http://linkedlifedata.com/resource/umls/relation/R120370240,
http://linkedlifedata.com/resource/umls/relation/R120370241,
http://linkedlifedata.com/resource/umls/relation/R120370242,
http://linkedlifedata.com/resource/umls/relation/R120370244,
http://linkedlifedata.com/resource/umls/relation/R120370245,
http://linkedlifedata.com/resource/umls/relation/R120370246,
http://linkedlifedata.com/resource/umls/relation/R120370247,
http://linkedlifedata.com/resource/umls/relation/R120370248,
http://linkedlifedata.com/resource/umls/relation/R120370249,
http://linkedlifedata.com/resource/umls/relation/R120370250,
http://linkedlifedata.com/resource/umls/relation/R120370251,
http://linkedlifedata.com/resource/umls/relation/R120370253,
http://linkedlifedata.com/resource/umls/relation/R120370254,
http://linkedlifedata.com/resource/umls/relation/R120370255,
http://linkedlifedata.com/resource/umls/relation/R120370257,
http://linkedlifedata.com/resource/umls/relation/R120370258
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