|
rdf:type |
|
|
calbc:hasCorrelation |
|
|
skos:exactMatch |
|
|
skos:definition |
MSH: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.,CSP: HMG coA reductase inhibitor which inhibits cholesterol biosynthesis and thus lowers blood cholesterol levels; also blocks isoprenylation of protein CAAX motifs.,NCI: A drug used to lower the amount of cholesterol in the blood. It is also being studied in the prevention and treatment of some types of cancer. Lovastatin is a type of HMG-CoA reductase inhibitor (statin).,PDQ: A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering activity and potential antineoplastic activity. Lovastatin is hydrolyszed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG
|
|
skos:inScheme |
|
|
skos:broader |
|
|
skos:narrower |
umls-concept:C0049613,
umls-concept:C0056170,
umls-concept:C0058091,
umls-concept:C0066487,
umls-concept:C0074554,
umls-concept:C0083168,
umls-concept:C0614149,
umls-concept:C0641137,
umls-concept:C0645780,
umls-concept:C0647464,
umls-concept:C0667696,
umls-concept:C0667698,
umls-concept:C0728780,
umls-concept:C0733675,
umls-concept:C0887159,
umls-concept:C0887160,
umls-concept:C1170013,
umls-concept:C1170046,
umls-concept:C1602612,
umls-concept:C2341509,
umls-concept:C2341521,
umls-concept:C2342113,
umls-concept:C2342116,
umls-concept:C2342119,
umls-concept:C2342122
|
|
skos-xl:prefLabel |
|
|
skos-xl:altLabel |
umls-label:A0017472,
umls-label:A0017498,
umls-label:A0081059,
umls-label:A0081060,
umls-label:A0086170,
umls-label:A0482982,
umls-label:A0482983,
umls-label:A0482984,
umls-label:A0538913,
umls-label:A0746185,
umls-label:A10335722,
umls-label:A10761432,
umls-label:A10761433,
umls-label:A10761579,
umls-label:A10767921,
umls-label:A10772810,
umls-label:A10797709,
umls-label:A11771879,
umls-label:A11914309,
umls-label:A11915952,
umls-label:A11916689,
umls-label:A12103164,
umls-label:A1307985,
umls-label:A16720627,
umls-label:A17878737,
umls-label:A17902832,
umls-label:A17927068,
umls-label:A17927069,
umls-label:A17975145,
umls-label:A17998940,
umls-label:A18022642,
umls-label:A18022643,
umls-label:A18592493,
umls-label:A18629689,
umls-label:A18629690,
umls-label:A18666906,
umls-label:A19039151,
umls-label:A4343727,
umls-label:A7571808,
umls-label:A8437846,
umls-label:A8481737
|
|
umls:relation |
http://linkedlifedata.com/resource/umls/relation/R28409689,
http://linkedlifedata.com/resource/umls/relation/R112184082,
http://linkedlifedata.com/resource/umls/relation/R28483024,
http://linkedlifedata.com/resource/umls/relation/R112184092,
http://linkedlifedata.com/resource/umls/relation/R01361726,
http://linkedlifedata.com/resource/umls/relation/R01361727,
http://linkedlifedata.com/resource/umls/relation/R01361728,
http://linkedlifedata.com/resource/umls/relation/R55154463,
http://linkedlifedata.com/resource/umls/relation/R112185900,
http://linkedlifedata.com/resource/umls/relation/R32103536,
http://linkedlifedata.com/resource/umls/relation/R32103535,
http://linkedlifedata.com/resource/umls/relation/R32103533,
http://linkedlifedata.com/resource/umls/relation/R32103534,
http://linkedlifedata.com/resource/umls/relation/R120353322,
http://linkedlifedata.com/resource/umls/relation/R120353323,
http://linkedlifedata.com/resource/umls/relation/R120353324,
http://linkedlifedata.com/resource/umls/relation/R120353326
|
