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skos:definition |
MSH: The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.,CSP: covalent DNA changes in cells during normal differentiation resulting in new sequences, expression, or gene products; mechanism of binding site diversification for antibodies, certain receptors, and possibly other proteins.,NCI: Any DNA sequence rearrangement that results in the creation of a novel protein-coding capacity. Within certain genes, gene rearrangement is a normal part of development, facilitating the affinity maturation of B and T lymphocytes as well as class switching of immunoglobulins.
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