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skos:definition |
MSH: A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II. EC 2.7.7.7.,NCI: An enzyme that has dual functionality in DNA synthesis. The protein has the ability to facilitate DNA synthesis by polymerase action and an exonucleolytic activity that degrades single stranded DNA in the 3' to 5' direction. This protein is essential for leading strand synthesis.
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