| umls-concept:C0010934 | skos:definition | MSH: A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015),NCI: An anticancer drug that is a type of antitumor antibiotic.,CHV: a kind of cancer treatment drug,CHV: a kind of cancer treatment drug,CHV: a kind of cancer treatment drug,PDQ: A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39675&idtype=1" active clin | lld:umls |
