| umls-concept:C0010763 | skos:definition | MSH: An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include alcohol; NITROSAMINES; BENZENE; URETHANE; and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.,NCI: Cytochrome P450 2E1 (493 aa, ~57 kDa) is encoded by the human CYP2E1 gene. This protein plays a role in the both the metabolism of drugs, ethanol and other xenobiotics and the oxidative activation of nitrosamines. | lld:umls |
