MSH: A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008),CSP: deficiency of blood coagulation factor IX inherited as an X-linked disorder; clinical features resemble those in hemophilia A, but patients present with fewer symptoms.,NCI: An X-linked inherited bleeding disorder caused by deficiency of the coagulation factor IX.