MSH: A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343),MEDLINEPLUS: <p>Charcot-Marie-Tooth disease (CMT) is a group of genetic nerve disorders. It is named after the three doctors who first identified it. In the United States, CMT affects about 1 in 3,300 people. </p><p>CMT affects your <a href='http://www.nlm.nih.gov/medlineplus/peripheralnervedisorders.html'>peripheral nerves</a>. Peripheral nerves carry movement and sensation signals between the brain and spinal cord and the rest of the body.