Source:http://linkedlifedata.com/resource/umls/id/C0006463
MSH: An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.,CSP: alkylating agent having a selective immunosuppressive effect on bone marrow; has been used in the palliative treatment of chronic myeloid leukemia.,NCI: An anticancer drug that belongs to the family of drugs called alkylating agents.,PDQ: A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. Check for "http:/