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skos:definition |
MSH: A sulfamyl diuretic.,CSP: 3-butylamino-4-phenoxy-5-sulfamoylbenzoic acid.,NCI: A potent sulfamoylanthranilic acid derivative belonging to the class of loop diuretics. In the brain, bumetanide may prevent seizures in neonates by blocking the bumetanide-sensitive sodium-potassium-chloride cotransporter (NKCC1), thereby inhibiting chloride uptake thus, decreasing the internal chloride concentration in neurons and may block the excitatory effect of GABA in neonates.
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