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skos:definition |
MSH: Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.,CSP: class of antidepressants with 3 ring chemical structures; mechanism unknown, but believed to involve serotonin metabolism, transport, or receptor sensitivity.,NCI: A type of drug used to treat depression.,NCI: Mood-stimulating agents which contain a tricyclic structure and are used primarily in the treatment of affective disorders and related conditions. This group of agents appear to act through brain catecholamine systems.
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