Statements in which the resource exists as a subject.
PredicateObject
rdf:type
calbc:hasCorrelation
skos:exactMatch
skos:definition
MSH: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.,CSP: semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.,NCI: A broad-spectrum, semi-synthetic, beta-lactam penicillin antibiotic with bactericidal activity. Ampicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Ampicillin is stable against hydrolysis by a variety of beta-lactamases, therefore, can be used in wide range of gram-positive and -negative infections.
skos:inScheme
skos:broader
skos:narrower
umls-concept:C0002683, umls-concept:C0052145, umls-concept:C0052865, umls-concept:C0054083, umls-concept:C0054144, umls-concept:C0059424, umls-concept:C0065514, umls-concept:C0066082, umls-concept:C0070243, umls-concept:C0075629, umls-concept:C0125457, umls-concept:C0147814, umls-concept:C0148374, umls-concept:C0253898, umls-concept:C0282052, umls-concept:C0290419, umls-concept:C0483427, umls-concept:C0541147, umls-concept:C0592062, umls-concept:C0592250, umls-concept:C0595007, umls-concept:C0613348, umls-concept:C0628633, umls-concept:C0700443, umls-concept:C0700801, umls-concept:C0700802, umls-concept:C0700944, umls-concept:C0700945, umls-concept:C0700946, umls-concept:C0718454, umls-concept:C0721567, umls-concept:C0722251, umls-concept:C0722696, umls-concept:C0722804, umls-concept:C0723787, umls-concept:C0723788, umls-concept:C0724526, umls-concept:C0812398, umls-concept:C1433254, umls-concept:C2193831, umls-concept:C2353773, umls-concept:C2948283, umls-concept:C3489528
skos-xl:prefLabel
skos-xl:altLabel
umls:relation
http://linkedlifedata.com/resource/umls/relation/R28411702, http://linkedlifedata.com/resource/umls/relation/R112184320, http://linkedlifedata.com/resource/umls/relation/R112184321, http://linkedlifedata.com/resource/umls/relation/R49862418, http://linkedlifedata.com/resource/umls/relation/R01360513, http://linkedlifedata.com/resource/umls/relation/R49862421, http://linkedlifedata.com/resource/umls/relation/R01360518, http://linkedlifedata.com/resource/umls/relation/R49862419, http://linkedlifedata.com/resource/umls/relation/R01360516, http://linkedlifedata.com/resource/umls/relation/R01360517, http://linkedlifedata.com/resource/umls/relation/R01360519, http://linkedlifedata.com/resource/umls/relation/R49862417, http://linkedlifedata.com/resource/umls/relation/R49862420, http://linkedlifedata.com/resource/umls/relation/R55154002, http://linkedlifedata.com/resource/umls/relation/R112184339
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