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skos:definition |
MSH: The artificial induction of GENE SILENCING by the use of RNA INTERFERENCE to reduce the expression of a specific gene. It includes the use of DOUBLE-STRANDED RNA, such as SMALL INTERFERING RNA and RNA containing HAIRPIN LOOP SEQUENCE, and ANTI-SENSE OLIGONUCLEOTIDES.,NCI: Any of various techniques to reduce the expression of a gene without eliminating it entirely. The reduced epression may be permanent or via a transient mechanism.
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