canonical Wnt receptor signaling pathway

Source:http://linkedlifedata.com/resource/umls/id/C2262808

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
calbc:hasCorrelation
skos:definition
GO: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [GOC:bf, GOC:dph, PMID:11532397, PMID:19619488]
skos:inScheme
skos-xl:prefLabel
skos-xl:altLabel