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NCI: Defined as patients with defined or presumed cardiac disease and one of the following: Class I: without limitations of physical activity. Ordinary physical activity does not cause undue fatigue, palpitation, or dyspnea. Class II: slight limitation of physical activity. They are comfortable at rest. Ordinary physical activity results in fatigue, palpitation, or dyspnea. Class III: marked limitation of physical activity. They are comfortable at rest. Less than ordinary activity causes fatigue, palpitation, or dyspnea. Class IV: inability to carry on any physical activity without discomfort. Symptoms are present even at rest or minimal exertion. (The Criteria Committee of the New York Heart Association. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed. Boston, Mass: Little, Brown & Co; 1994:253-256.) (NIH Roadmap Cardiovascular Data Standards Working Group),NCI: A finding associated with a patient based on the functional classification developed by the New York Hear
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