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NCI: Widely expressed by human GPRK6 Gene (GPRK Family), alternative isoforms A (576-aa) and B (589-aa) of membrane-bound 66-kDa G Protein-Coupled Receptor Kinase 6, containing an RGS domain and DLG and ENIL motifs, specifically Ser/Thr phosphorylate activated forms of GPCRs and may be involved in desensitization of D2/D3 dopamine receptors. (NCI)
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