Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| calbc:hasCorrelation | |
| skos:exactMatch | |
| skos:definition |
MSH: Compounds that inhibit the activity of DNA TOPOISOMERASE II.,NCI: Any substance that inhibits topoisomerase-II, a topoisomerase that relieves torsional stress in a DNA molecule by cutting both strands of the DNA double helix. A topoisomerase II inhibitor can either stabilize the DNA-protein complex or inhibit the catalytic activity of the enzyme. Inhibition of topoisomerase-II causes DNA damage, inhibition of DNA replication, and apoptosis.
|
| skos:inScheme | |
| skos-xl:prefLabel | |
| skos-xl:altLabel |