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| skos:definition |
NCI: Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide, encoded by the PIK3CA gene, belongs to the PI3/PI4-kinase family. Phosphatidylinositol 3 Kinase is a heterodimer of a P110 (catalytic) and a P85 (regulatory) subunit. It phosphorylates PTDINS, PTDINS4P and PTDINS(4,5)P2 with a preference for PTDINS(4,5)P2. (from Swiss-Prot)
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