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NCI: Encoded by human PRIM1 Gene (Eukaryotic Primase Small Subunit Family), 420-aa 49-kDa Primase Polypeptide 1 is the small subunit of heterodimeric DNA Primase. Eukaryotic DNA replication involves a chromosomal replication apparatus containing key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. Zinc bound to a PRIM1 zinc knuckle motif appears be involved in sequence recognition and binding of ssDNA. (NCI)
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