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NCI: Expressed in a variety of tissues (abundantly in erythroid stem cells to differentiated reticulocytes) by human MPP1 Gene (MAGUK Family), 466-aa 52-kDa Palmitoylated Membrane Protein 1 contains 1 PDZ/DHR domain, 1 conserved SH3 domain, 1 guanylate kinase-like domain, and a region that binds to cytoskeletal protein 4.1. Tightly associated with the plasma membrane and extensively palmitoylated, MPP1 interacts with DLG5 and is suspected to play a role in signal transduction. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)
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