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NCI: This protein is a member of the ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. (LocusLink),NCI: Encoded by human ADAM11 Gene (ADAM Family, Peptidase M12b Family), the 769-amino acid 83 kD (precursor) type I membrane ADAM11 Protein (isoforms MDC-769 and MDC-524) is implicated in cell-cell/-matrix interactions of muscle development, neurogenesis, and fertilization. Membrane-anchored ADAM zinc metalloproteases contain disintegrin domains related to snake venom disintegrins. A putative integrin ligand, ADAM11 is a metalloprotease-like noncatalytic protein predominantly express
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