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NCI: Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA. [EC 2.3.1.5 created 1961] (from IUBMB),NCI: Arylamine N-acetyltransferase, the encoded product of the NAT2 gene, is the polymorphic enzyme responsible for the "acetylator phenotype"; rapid or slow acetylation of therapeutic and carcinogenic agents is due to variation at the NAT2 locus. The slow phenotype results from decreased or absent arylamine N-acetyltransferase in the liver. A relationship appears to exist between acetylator phenotype and DNA damage by chemicals that undergo N-acetylation. Acetylation polymorphism may be a factor in susceptibility to toxicity and perhaps carcinogenicity of target chemicals. (from OMIM 243400 and NCI)
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