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skos:definition |
MSH: Transcription factors that form transcription initiation complexes on DNA, bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. Although their binding may be localized to distinct sequence and structural motifs within the DNA they are considered non-specific with regard to the specific gene being transcribed.,NCI: Basal Transcription Factors are prokaryotic and eukaryotic proteins that cooperate with DNA-dependent RNA polymerases to initiate, inhibit or terminate transcription.
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