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skos:definition |
MSH: Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.,NCI: A 20 to 25-nucleotide double-stranded RNA which is involved in a sequence-specific messenger RNA degradation process known as RNA interference.,CSP: short sequence of RNA which can be used to silence gene expression; small antisense RNAs that are generated from specific double stranded RNAs which trigger targeted messenger RNA degradation (RNA INTERFERENCE); serve as guides for cleavage of
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